The increasing frequency of penicillin and multidrug resistant pneumococci all over the world, has resulted in difficulties in the therapy of pneumococcal infections in recent years. The aim of this study is to investigate the rates of resistance to penicillin and other antimicrobial agents in Streptococcus pneumonia strains isolated from adult patients with community acquired lower respiratory tract infections in Manisa. Seventy-five strains were assessed in the study and penicillin resistance was evaluated by using oxacillin disc diffusion test and E-test methods. Resistance rates to the other antimicrobial agents were investigated by disc diffusion method. We found the rates of intermediate resistance and high resistance to penicillin as 18.6% and 1.4%, respectively. The rate of multi drug resistance (MDR) was found as 4.8%. MDR phenotypes, encountered in our region are associated with macrolide and trimethoprim/sulfamethoxazole resistance as well as penicillin resistance. No strain was found to be resistant to ofloxacin, vancomycin or meropenem. The rates of resistance to trimethoprim-sulphamethoxazole, erythromycin, clindamicin, gentamicin, cefaclor, aztreonam, amoxycillin-clavulanate, chloramphenicol and ceftriaxone were found as 17.9%, 17.2%, 8.3%, 4.1%, 4.1%, 2.1%, 1.4%, 0.7% and 0.7%, respectively. As the rate of penicillin resistance was low in our region, it can be concluded that penicillin can be the first choice in the therapy of community acquired pneumococcal pneumoniae.