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2004, Cilt 34, Sayı 3, Sayfa(lar) 171-174
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In Vitro Activities of Ofloxacin, Levofloxacin and Norfloxacin Against Multi-Drug Resistant Mycobacterium tuberculosis Strains
Meltem Uzun, Dilek Şatana, Sezer Dere
İstanbul University ,İstanbul Faculty of Medicine,Department of Microbiology and Clinical Microbiology, İstanbul
Keywords: M.tuberculosis , multi-drug resistant tuberculosis , fluoroquinolones

As the fluoroquinolones are novel anti-tuberculosis drugs to be used in multi-drug resistant tuberculosis (MDR-tb), minimal inhibitory concentrations (MIC's) of ofloxacin , levofloxacin and norfloxacin were investigated by radiometric proporsion method in 20 MDR Mycobacterium tuberculosis (M.tuberculosis) strains. MIC50 and MIC90 values of ofloxacin, levofloxacin and norfloxacin were found to be as 1μg/ml , 0.5 μg/ml , 5 μg/ml and 2μg/ml,

1 μg/ml, 10 μg/ml respectively. MIC values of levofloxacin were more lower than ofloxacin but the highest MIC values were obtained in norfloxacin. As a result, we concluded that ofloxacin and levofloxacin can be used as alternative drugs in the treatment of MDR-tb caused by the strains isolated from our laboratory.


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