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2002, Cilt 32, Sayı 3-4, Sayfa(lar) 207-211
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Frequencies of Extended Spectrum and Inducible Chromosomal Betalactamases in Gram Negative Bacteria Isolated from Hospitalized Patients
Otku Kandemir, Gülden Ersöz, Elif Şahin, Ali Kaya
Mersin Üniversitesi Tıp Fakültesi Klinik Mikrobiyoloji ve İnfeksiyon Hastalıkları Anabilim Dalı, Mersin
Keywords: Nosocomial Gram negative bacteria, extended spectrum beta lactamase, inducible beta lactamase, direct induction test, double disk synergy test

The presence of extended spectrum beta-lactamase, (ESBL) and inducible chromosomal beta-lactamase is studied from the 78 Gram negative bacteria, that are cultured from different material (blood, draning catheter, catheter tip, wound, urine, sputum etc) contained from those patients followed in Mersin University Hospital between May 2000 and June 2001. Double disk synergy test is used to detect ESBL whereas direct induction test is used to detect the inducible beta-lactamase. 30 of the isolates were Escherichia coli, 13 were Pseudomonas spp., 11 were Klebsiella pneumoniae, 7 were Enterobacter spp., 4 were Proteus spp., 3 were Klebsiella oxytoca, and 1 was Providencia spp., 1 was Serratia spp., and 1 was Morganella spp. Inducible beta-lactamase was present in 7 (%10) of the strains 11 (%15,4) strains were found to be ESBL positive. Routine antibiogram test revealed false results in 7 of 11 ESBL positive bacteria. All chromosomal inducible betalactamase positive Gram negative bacteria were sensitive to third generation cephalosporins and aztreonam in routine antibiogram. As a conclusion, we belive that special tests should bi used to define ESBL and chromosomal beta lactamases.

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