2000, Cilt 30, Sayı 3-4, Sayfa(lar) 176-179 |
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The Effect of Macrolides on Intracellular Killing of Staphylococcus aureus In Neutrophil Granulocytes |
Tanju Kadır1, Adile Çevikbaş2 |
1Marmara Üniversitesi, Dişhekimliği Fakültesi, Mikrobiyoloji Bilim Dalı, Nişantaşı-İstanbul 2Marmara Üniversitesi, Eczacılık Fakültesi, Farmasötik Mikrobiyoloji Anabilim Dalı, Haydarpaşa-İstanbul |
Keywords: Erithromycin, azithromycin, clarithromycin, neutrophil, intracellular killing |
In this study the in vitro effect of erithromycin, azithromycin and clarithromycin on the intracellular killing of S.aureus in human neutrophil granulocytes was invistigated Each drug was tested in concentrations of 0.25, 1, 2, and 20μg/ml and intracellular killing was measured for up to 4 h of incubation. Azithromycin increased significantlly (p<0.05) the intracellular killing in all concentrations, however erithromycin and clarithromycin increased the intracellular killing only in concentration of 20μg/ml. All 3 antibiotics increased the killing significantlly (p<0.05) in concentration of 20μg/ml relative to the control without antibotics.
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