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2003, Cilt 33, Sayı 1, Sayfa(lar) 085-091
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Investigation of the In Vitro Effect of Cefodizime on Polymorphonuclear Leucocyte Functions in Chronic Renal Failure Patients
Rıza Adalati1, Ümran Soyoğul Gürer2, Adile Çevikbaş2, Candan Johansson3
1Haydarpaşa Numune Hastanesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Servisi, Haydarpaşa, İstanbul
2Marmara Üniversitesi, Eczacılık fakültesi, Farmasötik Mikrobiyoloji Anabilim Dalı, Haydarpaşa, İstanbul
3Marmara Üniversitesi, Tıp Fakültesi, Mikrobiyoloji Anabilim dalı, Haydarpaşa, İstanbul
Keywords: Cefodizime, chronic renal failure, polymorphonuclear leukocyte functions

In this study, in vitro effect of cefodizime (1, 10, 100 μg/ml) on polymorphonuclear leukocyte ( PMN) functions ( phagocytosis and intracellular killing) on Candida albicans (C.albicans) blastospores was investigated in 11 chronic renal failure patients and 6 healthy volunteers. The effect of therapeutic concentrations of cefodizime on phagocytosis and candidacidal activity was studied.

Phagocytic activity of PMNs in chronic renal failure patients was enhanced after pretreatment of PMNs with cefodizime at 1 and 10 μg/ml concentrations (p < 0.05), candidacidal activity was enhanced a little but it was not statistically significant at same concentrations (p > 0.05). Cefodizime at 100 μg/ml concentration had no effect relative to the control PMNs on phagocytosis and intracellular killing ( p > 0.05).

In healthy volunteers, cefodizime at 1, 10 and 100 μg/ml concentration had no effect on phagocytosis and intracellular killing of C.albicans compared with control PMNs (p > 0.05).


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