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2003, Cilt 33, Sayı 2, Sayfa(lar) 109-114
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Trends of the Penicillin Resistance In Pneumococci
Oral Öncül1, Hakan Erdem2, Hüsnü Altunay1, M Fevzi Özsoy1 Alaadin Pahsa1, Şaban Çavuşlu1
1 GATA Eğitim Hastanesi İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Servisi, İstanbul
2 Sivas Asker Hastanesi İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Servisi, Sivas
Keywords: Streptococcus pneumoniae, penicillin, resistance

Streptococcus pneumoniae has an ongoing increasing importance with it's escalating antibiotic resistance. In this study, 7-year period of penicillin resistance in pneumococcal strains isolated in GATA Haydarpasa Training Hospital Infectious Diseases and Clinical Microbiology Department is presented.

The study was carried on without interruption between 1993-1997 (I.interval) and 1997-2000 (II. Interval). Penicillin resistance was investigated in 148 isolates by Mueller Hinton Broth Microdilution in the first interval and by E-test for 101 bacteria in the second period. The resistance interval was defined according to the NCCLS instructions and ATCC 29546 pneumococcal strain was used as the reference.

The penicillin resistance in the pneumococci was 12% in the first interval while 31% in the latter one (p<0.001). In addition, intermediate resistance (IR) elevated from 12% to 27% while 4% of the isolates encountered in the second period was higly resistant (HR) to penicillin compared with the absence of HR strains in the previous period. Especially it was observed that the resistance trend accelerates during 1999-2000 with respect to the preceding years.

The augmentation of penicillin resistance we detected in our study emphasizes that the burden of nonsusceptibility has reached noteworthy levels. It was concluded that applying mass measures and providing multidisciplinary approaches are necessary for the struggle in bacterial resistance.


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