Ana Sayfa | Dergi Hakkında | Yayın Kurulu | Telif Hakkı Devir Formu | Arşiv | Yayın Arama | Yazarlara Bilgi | Etik Politikalar | İletişim  
2003, Cilt 33, Sayı 4, Sayfa(lar) 315-322
[ Türkçe Özet ] [ PDF ] [ Benzer Makaleler ]
Virulence Factors of Candida parapsilosis Strains Isolated from Hospitalized Fungemic Patients
Meltem Dağdeviren1, Nilgün Çerikçioğlu1, Melda Karavuş2
1Marmara Üniversitesi, Tıp Fakültesi, Mikrobiyoloji Anabilim Dalı, İstanbul
2Marmara Üniversitesi, Tıp Fakültesi, Halk Sağlığı Anabilim Dalı, İstanbul
Keywords: Candida parapsilosis, adherence, acid proteinase, phospholipase

In this study, we investigated the presence of the virulence factors including adherence, acid proteinase and phospholipase production capabilities of 33 Candida parapsilosis strains of which 19 were isolated from blood cultures of hospitalized fungemic patients (study group 1) and 14 were isolated from non-blood clinical materials (study group 2). We also investigated the importance of present factor or factors in the development of fungemia. The mean of adherence values of 19 blood isolates and 14 non-blood isolates were found to be 52.63 and 57.96, respectively. For adherence capability, there was no significant difference between the two groups (p>0.05). Nine non-blood strains (64.29%) of study group 2 and five blood strains (26.31%) of study group 1 were found to be positive for acid proteinase production; this difference was statistically significant (p<0.05). Phospholipase production was found in five strains (26.31%) of 19 blood isolates. None of 14 non-blood strains exhibited phospholipase activity; this difference between the two groups was statistically significant (p<0.05). In this study, correlation between adherence-phospholipase, adherence-acid proteinase properties of strains was detected as well.

In the present study, it has been suggested that phospholipase production can be an important virulence factor in bloodstream infections caused by Candida parapsilosis.


[ Türkçe Özet ] [ PDF ] [ Benzer Makaleler ]
Ana Sayfa | Dergi Hakkında | Yayın Kurulu | Telif Hakkı Devir Formu | Arşiv | Yayın Arama | Yazarlara Bilgi | Etik Politikalar | İletişim