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2003, Cilt 33, Sayı 3, Sayfa(lar) 252-256
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In Vitro Susceptibility to Amphotericin B and Fluconazole of Candida Strains Isolated from Blood Cultures
Nurver Ülger Toprak 1, Seda Erdoğan 2, Cennet Çelik 1, Candan Johansson 3
1Marmara Üniversitesi Tıp Fakültesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dalı, İstanbul
2 Biofarma İlaç Sanayi ve Ticaret A.Ş, İstanbul
3 Maltepe Üniversitesi Tıp Fakültesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dalı, İstanbul
Keywords: Cadidemia, Candida, antifungal susceptibility, amphotericin B, fluconazole

The aim of this study was to evaluate the susceptibilities of Candida strains isolated from blood cultures to amphotericin B and fluconazole and to get a view for the empirical treatment. Candida strains isolated from 60 patients' blood cultures within the time period of May 1999- November 2000 were included in the study. The strains were identified by standard mycological methods. Antifungal susceptibility tests were performed and interpreted in accordance with the macrodilution method recommended by NCCLS (M27A). Pure Candida spp. were isolated from 57 patients' blood, and three specimens exhibited mixed Candida culture. Of 63 test isolates, 97% were Candida spp and the remaining 3% Trichosporon asahii. Candida albicans constituted the most common species (40%), followed by C.parapsilosis (35%) and C.tropicalis (13%). All Candida strains. were susceptible to amphotericin B. Except the intrinsically fluconazole resistant C.krusei, non of Candida isolates were resistant to fluconazole.

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