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2007, Cilt 37, Sayı 2, Sayfa(lar) 098-102
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Comparison of serum antigliadin and antiendomysium antibodies in patients with Familial Mediterranean Fever
Özlem Yılmaz1, Sevin Kırdar1, Yavuz Doğan1, Salih Kavukçu2, Sülen Sarıoğlu3, Erbil Ünsal2, İ. Hakkı Bahar1, Nuran Yuluğ1
1Dokuz Eylul University Faculty of Medicine, Department of Microbiology and Clinical Microbiology, Izmir
2Dokuz Eylul University Faculty of Medicine, Department of Pediatrics, Izmir
3Dokuz Eylul University Faculty of Medicine, Department of Pathology Izmir
Keywords: Familial Mediterranean fever, coeliac disease, diagnosis, anti-gliadin antibodies, anti-endomysium antibodies, indirect immunofluorescence, enzyme-linked immunosorbent assay

This study was conducted to investigate the prevalence and clinical relevance of antiendomysium (EmA) and antigliadin (AGA) antibodies at the onset of Familial Mediterranean Fever (FMF) patients by serological methods. The high levels of AGA and EmA have been reported in patients with severe abdominal pain. Although it has been pointed out that coeliac disease (CD) has been shown to be associated with many different diseases, the relationship between the CD and FMF, in which main sign is abdominal pain, has not been investigated so far. A total of 25 children ( ages between 5 to 17 years ) were included in this study. Fifteen of them were FMF patients having abdominal cramps and discomfort, ten were healthy controls. AGA IgA and IgG antibodies were detected by a commercial ELISA (Euroimmun), EmA IgA and AGA IgA antibodies were determined by indirect immunofluorescence test (IFA, Euroimmun). Six (40%) FMF patients were found positive for AGA IgG, two (13.3%) were found positive for AGA IgA by ELISA, four (26.6%) were positive for EmA IgA and two (13.3%) were positive for AGA IgA antibodies by IFA. Statistical analysis revealed that there was statistical difference ( p= 0.05, Fisher's chi-square test) for AGA IgG antibodies by ELISA between FMF patients and controls. There was no statistical difference for AGA IgA by ELISA, AGA IgA and EmA IgA by IFA,. Those found to be AGA IgG and IgA positive and/or EmA IgA positive by both methods could not be further investigated with the intestinal biopsy. In order to determine the accuracy of AGA and EmA antibodies for the diagnosis of CD in FMF children with digestive symptoms, it is necessary to search for these antibodies among larger FMF patient group.

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