2007, Cilt 37, Sayı 3, Sayfa(lar) 147-151 |
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Susceptibility of Streptococcus pneumoniae strains to widely used antibiotics in the treatment |
Neriman Balaban1, İpek Mumcuoğlu1, Nükhet Hayırlıoğlu1, Zeynep Ceren Karahan2, Nedim Sultan3, Hürrem Bodur4 |
1Ankara Numune Eğitim ve Araştırma Hastanesi Mikrobiyoloji ve Klinik Mikrobiyoloji Laboratuvarı, Ankara 2Ankara Üniversitesi, Tıp Fakültesi Mikrobiyoloji ve Klinik Mikrobiyoloji AD, Ankara 3Gazi Üniversitesi, Tıp Fakültesi Mikrobiyoloji ve Klinik Mikrobiyoloji AD, Ankara 4Ankara Numune Eğitim ve Araştırma Hastanesi II. İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Servisi, Ankara |
Keywords: Streptococcus pneumoniae, penicillin resistance, E test |
The worldwide increase of resistance to penicillin and other widely used antibiotics prefered in the treatment of S. pneumoniae infections has become a serious problem within the last 20 years. Antimicrobial resistance of 78 S. pneumoniae strains, which isolated from clinical samples between June 2004 and May 2005, to penicillin, erythromycin, azithromycin, trimethoprim- sulfamethoxazole, cefotaxime, cefuroxime, doxycycline, ofloxacin and levofloxacin were determined by E test method (AB-Biodisk, Sweeden). The rates of penicilin resistance and intermediate resistance of strains were 7.7% and 21.8% respectively. The highest resistance rates was detected for trimethoprim-sulfametaxazole (28.2%), azithromycin (16.7%) and erythromycin (14.1%). All penicillin resistant isolates and 82.4% of the penicillin intermediate resistant isolates were resistant to at least two antibiotics.
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