The aim of the study was to evaluate patients with the HBeAg positive chronic hepatitis B as biochemical, serological and clinically between Januay 2003-December 2004. Twelve patients ( 9 male, mean age 31) were enrolled in the study. Mean ALT levels of nine patients were 30 U/L but it was elevated in three patients (76,105,237 U/L). HBV DNA (by hibridization) was studied in seven patients and it was positive in four (% 57) and negative in three (43 %) ones. Anti-HCV, anti-HDV and anti- HIV were negative in all patients. During following period HBeAg/anti-HBe seroconversion developed in one (8.3 %) patient after 39 months. There was not any space occupying lession in ultrasonography. In conclusion; in major of chronic hepatitis B patients transmission was thought to be vertical. In long term following period, in this group, rate of seroconversion is high and complication ratio is low. Twelve months intervals for monitoring of this group is sufficient but while the liver function test is high the following period should be closer.