Ana Sayfa | Dergi Hakkında | Yayın Kurulu | Telif Hakkı Devir Formu | Arşiv | Yayın Arama | Yazarlara Bilgi | Etik Politikalar | İletişim  
2007, Cilt 37, Sayı 4, Sayfa(lar) 196-200
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Detection of antimicrobial susceptibilities and beta-lactamase production of Moraxella catarrhalis strains isolated from various clinical samples by isoelectric focusing
Sinem Özdemir, Nevriye Gönüllü
İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dalı, İstanbul
Keywords: Moraxella catarrhalis, antibiotic susceptibilitiy, isoelectric focusing

In this study, we aimed to determine the prevalence of antimicrobial susceptibilities of Moraxella catarrhalis strains and the identification of BRO beta-lactamases. Our study included 50 M.catarrhalis strain isolated from various clinical samples (45 sputum, 2 throat smear, 1 nose leakage smear, 1 hemoculture, 1 endotracheal aspirate) in the Department of Microbiology and Clinical Microbiology of Cerrahpasa Faculty of Medicine. The antimicrobial susceptibilities of strains against ampiciline, cefuroxime, cefotaxime, ceftriaxone, erythromicine, clindamicine, tetracycline, gentamycin, ciprofloxacine were detected by the agar dilution method with the recommendations of Clinical and Laboratory Standarts Institute. Moreover, betalactamases of M.catarrhalis strains were typed by isoelectric focusing method. Beta-lactamases positivity was detected in 47 (94%) of the M.catarrhalis strains by nitrocephin disc test. Three (6%) of the M. catarrhalis strains showed no beta-lactamases. 41 (87.2%) and six (12.8%) of the BRO beta- lactamases were identified as BRO-1 and BRO-2, respectively.

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