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2008, Cilt 38, Sayı 3-4, Sayfa(lar) 112-116
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Antibiotic susceptibilities and beta-lactam resistance phenotypes of Pseudomonas aeruginosa strains isolated from various clinical samples
Özlem Güven, Derya Ünver, Sinem Özdemir, Nevriye Gönüllü, Ömer Küçükbasmacı, Kemal Altaş
İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dalı, İstanbul
Keywords: Pseudomonas aeruginosa, antibiotic susceptibility, fosfomycin, beta-lactam resistance phenotype

Pseudomonas aeruginosa is an opportunistic pathogen that causes severe sistemic infections and antibiotic resistance in P.aeruginosa is a serious problem. The antibiotic susceptibilities and the various phenotypes of beta-lactam resistance in 161 P.aeruginosa strains isolated from various clinical specimens over a period of a year in the Department of Microbiology and Clinical Microbiology of Cerrahpasa Faculty of Medicine Hospital were investigated. The fosfomycin susceptibilities of the isolates were also detected. The disc diffusion test was used as a simple method to determine the beta-lactam resistance phenotypes of P.aeruginosa. The lowest resistance rates were found to imipenem and amikacin (34%). The fosfomycin susceptibility rate was 60%. Beta-lactam resistance phenotypes of the isolates are low-level penicillinase (1, 9%), high-level penicillinase (3, 7%), nonenzymatic (8, 7%), cephalosporinase (14, 3%), selective impermeability to imipenem (2, 5%), extended spectrum beta-lactamase (1, 2%) and complex phenotype (29, 2%).

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