Th is is a case report on the first isolation of Rahnella aquatilis, a very rare enteric Gram negative rod, from bone and soft tissue of a foot of a patient with diabetes. Previous reports of isolation of R. aquatilis from patients are also summarized. It is concluded that clinical microbiologists must be aware of the diff erential characteristics of this rare microorganism, which is likely to be resistant to ampicillin and cephalothin, particularly in immunocompromised patients.