Ana Sayfa | Dergi Hakkında | Yayın Kurulu | Telif Hakkı Devir Formu | Arşiv | Yayın Arama | Yazarlara Bilgi | Etik Politikalar | İletişim  
2010, Cilt 40, Sayı 1, Sayfa(lar) 022-026
[ Türkçe Özet ] [ PDF ] [ Benzer Makaleler ]
Determination of the in Vitro Effect of Deuterium Depleted Water on Polymorphonuclear Leukocyte Functions in Healthy Young Volunteers
Ümran Soyoğul Gürer1, Koray Derici1, Burçak Gürbüz1, Pervin Rayaman1, Adile Çevikbaş1, Turay Yardımcı2
1Marmara Üniversitesi, Eczacılık Fakültesi, Farmasötik Mikrobiyoloji Anabilim Dalı, Haydarpaşa/İstanbul
2Marmara.Üniversitesi, Eczacılık Fakültesi, Biyokimya Anabilim Dalı, Haydarpaşa/İstanbul
Keywords: Deuterium depleted water, polymorphonuclear leukocytes functions, phagocytosis

Objective: Natural water contains 150 ppm (parts per million) of deuterium (an isotope of hydrogen), which is within the acceptable limits for most healthy people. Lowered deuterium content can affect the diseased cells in the body while having no effect on healthy blood cells. Today it is known that frequently used antineoplastic agents, analgesics and antibiotics affect the immune system cells and can modify polymorphonuclear leukocyte functions such as phagocytosis, lymphocyte proliferation and production of various cytokines. The aim of this study was to determine the effect of deuterium depleted water (29 ppm) on phagocytosis and intracellular killing activity of polymorphonuclear leukocytes in healthy young volunteers.

Materials and Methods: 10 healthy young volunteers were included in the study. Ficoll-hypaque gradient centrifugation was used to isolate polymorphonuclear leukocytes from venous blood. Phagocytosis and intracellular killing activity of polymorphonuclear leukocytes were assayed using a modification of Alexander's method.

Results and conclusion: When the effect of deuterium depleted water on polymorphonuclear leukocytes were evaluated, it was found that depletion of deuterium didn't significantly affect the polymorphonuclear leukocyte phagocytic and intracellular killing activities.


[ Türkçe Özet ] [ PDF ] [ Benzer Makaleler ]
Ana Sayfa | Dergi Hakkında | Yayın Kurulu | Telif Hakkı Devir Formu | Arşiv | Yayın Arama | Yazarlara Bilgi | Etik Politikalar | İletişim