Ana Sayfa | Dergi Hakkında | Yayın Kurulu | Telif Hakkı Devir Formu | Arşiv | Yayın Arama | Yazarlara Bilgi | Etik Politikalar | İletişim  
2010, Cilt 40, Sayı 1, Sayfa(lar) 037-040
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The Investigation of Antimicrobial Resistance and Metallo-Beta-Lactamase Production of Pseudomonas aeruginosa Strains Isolated from Intensive Care Unit Patients
Filiz Arabacı1, Mehmet Oldacay2
1Çanakkale Devlet Hastanesi Enfeksiyon Hastalıkları Servisi
2Çanakkale Devlet Hastanesi Mikrobiyoloji Servisi
Keywords: Pseudomonas aeruginosa, antimicrobial resistance, metallo-beta-lactamases

Objective: The aim of this study was to investigate the antimicrobial resistance and metallo-beta-lactamase production rates of Pseudomonas aeruginosa strains isolated from patients hospitalized at intensive care unit of Çanakkale State Hospital between January 2008-January 2009.

Materials and Methods: The antimicrobial susceptibilities of 108 P. aeruginosa strains were evaluated prospectively according to CLSI M100-S18 guidelines and metallo-beta-lactamase production was investigated by double-disk synergy method .

Results: Imipenem resistance was found in 20 (18.5%) of the strains and 14 (70%) of imipenem resistant strains were phenotypically metallo-beta-lactamase positive.

Conclusion: These results indicated high rate of phenotypic metallo-beta-lactamase positivity in carbapenem resistant P. aeruginosa strains isolated in the ICU. However, this phenotypic metallo-beta-lactamase production should further be investigated to enlighten the genetic basis of carbapenem resistance in these nosocomial P.aeruginosa isolates.


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