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2010, Cilt 40, Sayı 2, Sayfa(lar) 079-086
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Nasal Staphylococcus aureus Carriage and Evaluation of Related Risk Factors in Hemodialysis Patients
Gülperi Çelik1, Aynur Gülcan2
1Kütahya Devlet Hastanesi Nefroloji Bölümü, Kütahya
2Kütahya Devlet Hastanesi Mikrobiyoloji Bölümü, Kütahya
Keywords: Hemodialysis, Staphylococcus aureus carriage, antibiotic resistance

Objective: This study was aimed to determine the nasal carriage rates of Staphylococcus aureus, their antibiotic resistance rates and related risk factors for hemodialysis patients in Kütahya region.

Materials and Methods: S. aureus carriage was investigated in a total of 127 patients undergoing hemodialysis in Kütahya region. Swab specimens were obtained from the nostrils and the results of the cultures were evaluated. Antibiotic susceptibilities of the isolates were tested by Kirby Bauer disc diffusion method. Age, gender, inhabitance, duration of dialysis, accompanying disease, history of prior hospitalization and antibiotic use, and smoking history were the investigated risk factors.

Results: S. aureus carriage was determined in 41 (32.3%) patients. Five of these (3.9%) patients carried methicillin resistant S. aureus. Resistance rates were 90.2% to penicillin, 12.2% to oxacillin, 24.4% to trimethoprim sulfamethoxazole, 7.3% to rifampicin, 14.6% to ciprofloxacin, 24.4% to erythromycin, and 7.3% to clindamycin. Mupirocin resistance was 20% in the methicillin resistant S. aureus and 2.8% in the methicillin susceptible S. aureus group. No resistance were detected against vancomycin and linezolid. Statistically significant relationship was determined for S. aureus carriage and accompanying gastrointestinal disease and prior antibiotic use within the last year (p<0.05).

Conclusion: Screening S. aureus nasal colonization is very important in hemodialysis patients since intravascular device infections and sepsis due to S. aureus are a common cause of morbidity among these patients. Early detection of S. aureus carriage among hemodialysis patients may help to prevent the development of disease due to these agents and thus increase patient survival and reduce the health costs.


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Ana Sayfa | Dergi Hakkında | Yayın Kurulu | Telif Hakkı Devir Formu | Arşiv | Yayın Arama | Yazarlara Bilgi | Etik Politikalar | İletişim