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2011, Cilt 41, Sayı 1, Sayfa(lar) 037-041
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Resistance Rates of Mycobacterium tuberculosis complex Strains to the Primary Anti-tuberculosis Drugs in Sivas Province, Turkey
Cem ÇELİK, Fatma DAYI, Rakibe KAYGUSUZ, M. Zahir BAKICI
Cumhuriyet Üniversitesi Tıp Fakültesi Uygulama ve Araştırma Hastanesi Klinik Mikrobiyoloji Laboratuvarı, Sivas
Keywords: M. tuberculosis complex, anti-tuberculosis drugs

Objective: The aim of this study was to determine anti-tuberculosis drug susceptibilities of Mycobacterium tuberculosis complex (MTBC) strains, isolated from patients with initial diagnosis of tuberculosis during 2006-2010 at Cumhuriyet University Medical Faculty Application and Research Hospital.

Materials and Methods: Streptomycin, isoniazid, rifampicin and ethambutol susceptibility results of 189 MTBC strains, isolated from various clinical samples obtained from patients with suspected tuberculosis during the five year period between 2006 and 2010 were retrospectively evaluated.

Results: Resistance to primary anti-tuberculosis drugs wasn't observed in 159 of the 189 MTBC strains (84.1%). In 30 of these strains (15.9%), resistance to at least one or more primary anti-tuberculosis drugs was observed. The highest resistance rate was against isoniazid (3.7%) and streptomycin (3.7%). However, rifampicin (1.1%) and ethambutol (0.5%) resistance rates were lower. In 13 (6.9%) of the strains examined, resistance to more than one drug was observed. Isoniazid+rifampicin resistance was detected in 1.1%, isoniazid+streptomycin in 5.3% and isoniazid+streptomycin+rifampicin in 0.5% of the strains. Rate of multidrug resistant tuberculosis was found as 1.6%.

Conclusion: Since the rate of resistance to anti-tuberculosis drugs is in an incremental trend in our country, it is necessary to survey resistance in different regions of the country. Thus, the results of this study will contribute to the anti-tuberculosis drug resistance data in Turkey and help to guide tuberculosis therapy.


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