2011, Cilt 41, Sayı 4, Sayfa(lar) 131-138 |
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Anti Quorum Sensing Compounds Obtained From Plants and Their Potential in Developing New Drugs |
Elif ÇEPNİ1, Filiz GÜREL2 |
1İstanbul Üniversitesi, Moleküler Biyoloji ve Genetik Bölümü 2Ebittek Biyoteknoloji Araştırma Geliştirme Tic. Ltd. Şti. İstanbul Teknokenti |
Keywords: Quorum sensing, drug, biomonitor |
Quorum sensing (QS) is a mechanism of particular functions carried out by cell to cell communication provided by signal molecules. These functions include virulence protein synthesis, biofilm formation and DNA transport which are pathogenic traits. Most important problem on the control of the bacterial infections today, is the multi-drug resistance developed by the bacteria and selection of antibiotic resistant strains. Control of the bacterial pathogenecity by inhibition of QS mechanism was first achieved in human pathogen Pseudomonas aeruginosa. Recently, there has been an increase in studies showing the presence of anti-QS compounds in plant species. These species include rare or prevalent plants or medicinal plants with anti-bacterial effects. Various assays for anti-QS activity have been performed by using plant extracts prepared with different solvents. Anti-QS activity can be assayed by decreasing pigment production in Chromobac-terium violaceum, production of virulance factors, inhibition of biofilms as well as by using recombinant strains. Mechanism of QS inhibition was examined in a scarce numbers of species. Obtainment of chemical constituents from extracts and enlighting the exact mechanism of their QS inhibition will contribute to the development of new generation drugs.
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