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2011, Cilt 41, Sayı 4, Sayfa(lar) 143-148 |
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In Our Country, the Changing Epidemiology of Hepatitis A Infection |
Kamuran TÜRKER1, Elçin BALCI2, Sema BATI3, Medine HASÇUHADAR4, Eda SAVAŞ5 |
1İstanbul Bağcılar Eğitim Araştırma Hastanesi Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Bölümü 2Kayseri Erciyes Üniversitesi Tıp Fakültesi Halk Sağlığı Anabilim Dalı 3Ankara Dr. Abdurahman Yurtarslan Eğitim ve Araştırma Onkoloji Hastanesi Mikrobiyoloji Bölümü 4Ankara Atatürk Eğitim ve Araştırma Hastanesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Bölümü 5Gaziantep Ünaldı Aile Sağlığı Merkezi |
Keywords: Hepatitis A virus, public health, outbreak |
Objective: Hepatitis A virus (HAV) which is common all over the world, is transmitted by fecal oral route. It has been known that the complications of HAV infection increases with increasing age. In contrast to the previous data, incidence of hepatitis A is decreased in our country and in the neighbouring countries and the disease age is currently shifting to an advanced age leading to the development of a large population susceptible to HAV. This study was aimed to investigate the impact of civilization on HAV seropositivity and to determine the HAV susceptible population in our country.
Materials and Methods: The medical records of patients admitted to Dr. Abdurahman Yurtarslan Education and Training Oncology Hospital, Ankara between 01.03.2008-03.08.2010 and tested for anti-HAV IgG were reviewed retrospectively. Anti-HAV IgG was tested by Architect 2000 chemiluminescence method (Abbott Laboratories, Illinois, USA). Results: A total of 4606 patients, 2113 (45.9%) male and 2493 (54.1%) female, were included in the study. The mean age was 35.1 years (range=0-110 years). Anti HAV IgG positivity was detected in 3721 (80.8%) patients. Of the 885 anti-HAV IgG negative patients, 391 (44.2%) were male and 494 (55.8%) were female. Despite increasing anti-HAV IgG positivity with increasing age, 73% of the patients in 0-14 years age group, 66.1% in 0-19 years age group, and 60.1% in 0-24 years age group were anti-HAV IgG negative. Conclusion: The results of this study indicated that a significant part of children, adolescent and young adult population is currently susceptible to HAV infection. The destructive effects of possible HAV outbreaks in this susceptible population during school, military service or business life might be prevented by effective vaccination against HAV. |
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