2015, Cilt 45, Sayı 4, Sayfa(lar) 175-180 |
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Antimicrobial Susceptibility of Klebsiella Strains Isolated From Blood Cultures within a Five Year-Period in A Training and Research Hospital |
Asuman GÜZELANT, Meral KAYA, Hülya İren GÜVENÇ, Oya AKKAYA, Şerife YÜKSEKKAYA, Ayşegül OPUŞ, Habibe ÖVET, Muhammet Güzel KURTOĞLU |
Konya Eğitim ve Araştırma Hastanesi, Tıbbi Mikrobiyoloji Eğitim Kliniği, Konya |
Keywords: Klebsiella spp., antimicrobial agent, susceptibility |
Objective: Isolation of bacteria from blood culture plates is usually
indicative of a serious invasive infection which requires an urgent
antimicrobial therapy. Bacteremia and sepsis have high mortality
and morbidity rates. In general, gram negative bacteria are the
predominant cause of neonatal sepsis and among them, Klebsiella
pneumoniae is the most common pathogen especially in developing
countries. Microorganisms isolated from patients usually have
different antimicrobial susceptibilities. Hence, successful treatment
depends on prompt administration of appropriate antimicrobials.
Treatment of hospital-acquired infections caused by K. pneumoniae
may be difficult because many strains are highly resistant to many
broad-spectrum antimicrobials. The aim of this study is to determine
antimicrobial susceptibilities of Klebsiella strains isolated from
blood cultures, and to assess the most effective empirical antimicrobial
therapy for our hospital-acquired Klebsiella infections.
Material and Methods: In the present study, clinical Klebsiella
strains isolated from various clinics of Konya Training and Research
Hospital between January 2009 and December 2013 were used.
Bacterial identification and antimicrobial susceptibility tests were
performed by using conventional methods and Phoenix system
(Becton Dickinson Sparks, USA).
Results: One hundred and seventy- nine Klebsiella strains isolated
from blood cultures were included in the study. The most frequently
isolated strain was K. pneumoniae spp (n=158; 88.2%). The
detection rate of extended spectrum beta lactamase (ESBL)
producing Klebsiella spp was 54.18%. Ertapenem (98.53%) was the
most effective antimicrobial against Klebsiella isolates followed by
meropenem (97.17%), imipenem (94.70%), and amikacin
(93.74%).
Conclusion: Since the rate of ESBL producing strains was quite
high, beta lactam antibiotics should not be preferred for the
empirical treatment of hospital-acquired Klebsiella infections. In
conclusion, as a vital issue each hospital should determine its own
antimicrobial susceptibility patterns for the selection of the most
optimal empirical antimicrobial therapy.
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