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2016, Cilt 46, Sayı 1, Sayfa(lar) 001-007
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The Rising Star of In-Vivo Infection Models: Galleria mellonella Larvae
Meral KARAMAN
Dokuz Eylül Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, İzmir
Keywords: In vivo, infection model, Galleria mellonella larvae

Mammalian models have been frequently used in investigating the pathogenesis of infectious diseases. Ethical concerns about the use of mammals as well as difficulties related to hardware and financial problems bring invertebrates into agenda as alternative hosts. Invertebrate models such as the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans are used as alternatives. In recent years, however, Galleria mellonella larva attracts attention as a host model. Galleria mellonella larva, also known as the Greater Wax Moth, has several advantages compared to the other invertebrates, in investigations on pathogenesis of infection. Larvae, providing easy handling due to their large size (2-4 cm), and having the ability to survive at 15-37°C, are used for testing virulence factors of various medically important microorganisms. Comparative studies have demonstrated that Galleria mellonella larvae can be safely used in the characterization and identification of microbial virulence factors and in testing the effectiveness of antimicrobial peptides. In this review article we have discussed the prominent features of Galleria mellonella larvae, the shining star of the last decade, especially in the studies on the pathogenesis of infection.

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