2016, Cilt 46, Sayı 1, Sayfa(lar) 001-007 |
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The Rising Star of In-Vivo Infection Models: Galleria mellonella Larvae |
Meral KARAMAN |
Dokuz Eylül Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, İzmir |
Keywords: In vivo, infection model, Galleria mellonella larvae |
Mammalian models have been frequently used in investigating
the pathogenesis of infectious diseases. Ethical concerns
about the use of mammals as well as difficulties related to
hardware and financial problems bring invertebrates into
agenda as alternative hosts. Invertebrate models such as the
fruit fly Drosophila melanogaster and the nematode
Caenorhabditis elegans are used as alternatives. In recent
years, however, Galleria mellonella larva attracts attention
as a host model. Galleria mellonella larva, also known as
the Greater Wax Moth, has several advantages compared to
the other invertebrates, in investigations on pathogenesis of
infection. Larvae, providing easy handling due to their large
size (2-4 cm), and having the ability to survive at 15-37°C,
are used for testing virulence factors of various medically
important microorganisms. Comparative studies have
demonstrated that Galleria mellonella larvae can be safely
used in the characterization and identification of microbial
virulence factors and in testing the effectiveness of
antimicrobial peptides. In this review article we have
discussed the prominent features of Galleria mellonella
larvae, the shining star of the last decade, especially in the
studies on the pathogenesis of infection.
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