Objective: In this study evaluation of 2015-2016 influenza surveillance results of Influenza Reference Laboratory of Istanbul University, Medical Faculty was aimed.

Material and Methods: Influenza viruses in nasal swab samples, which were sent to the Influenza Reference Laboratory in Istanbul University, Medical Faculty Virology and Basic Immunology Division within the context of the Influenza Surveillance, were investigated using real-time PCR method.

Results: A total 2024 nasal swab samples were investigated at the Influenza Reference Laboratory at the 20th week of 2015-2016 flu season. Influenza virus was detected in 610 (30%) of the investigated samples. Three hundred and nineteen (52%) positive samples were identified as influenza A (H1N1) pdm09, 201 (33%) as influenza A H3N2 and 90 (15%) as influenza B.

Conclusion: Surveillance studies are extremely important for unveiling the effects of flu on public health and determining the methods for fighting against flu. According to our results the 17-51th weeks in 2015-2016 flu season were determined to be the activation time, while the peak period occurred in the 3rd week with influenza A (H1N1) pdm09 dominancy.