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2017, Cilt 47, Sayı 1, Sayfa(lar) 021-025
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Interpretation of Antibiotic Susceptibility Test Results of Pseudomonas aeruginosa, Acinetobacter baumannii and Escherichia coli Isolates According to EUCAST and CLSI: Hacettepe Experience
Salih MAÇİN1, Yakut AKYÖN YILMAZ2, Özben ÖZDEN2
1Şırnak Devlet Hastanesi, Mikrobiyoloji Laboratuvarı, Şırnak
2Hacettepe Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Ankara
Keywords: Acinetobacter baumannii, Antibiotics, CLSI, Escherichia coli, EUCAST, Pseudomonas aeruginosa

Objective: Antibiotic susceptibility tests (AST) provide an important contribution to the rational use of antibiotics. Two standard guidelines are commonly used for the application of test results worldwide. In our country CLSI guidelines have been used up to recent years, but currently a transition to implementation of EUCAST standards has begun. With the adoption of the new standards, the current epidemiological data should be compared with the previous data so as to to reveal the antibiotics which should be paid attention . The aim of this study was to analyse the effects of changes in clinical cut-off values in CLSI and EUCAST guidelines on AST reports.

Material and Methods: A total of 1650 antimicrobial test results which were reported according to CLSI standards in Hacettepe University Clinical Microbiological Laboratory from 1 January 2012 to 31 December 2013 were included in the study.

Results: Resistance rates were found to be nearly similar according to CLSI and EUCAST standards. Highest difference was found in Pseudomonas aeruginosa and levofloxacin (9.7%); also there were differences in ciprofloxacin (7%) for P. aeruginosa. In Acinetobacter baumannii there were minor differences in amikacin (2.8%) and levofloxacin (1.7%). In Escherichia coli, ciprofloxacin (1.2%), amoxicillin-clavulanate (2.5%), cefepime (1.6%) and ceftazidime (4.2%) differed slightly in EUCAST.

Conclusion: In our country, CLSI guidelines are being replaced by EUCAST guidelines. In this study, antimicrobial susceptibility results interpreted by CLSI guidelines were reinterpreted according to EUCAST cut-off values and changes in the susceptibility categories were assessed. These differences should be taken into account when EUCAST standards are employed.


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