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2017, Cilt 47, Sayı 2, Sayfa(lar) 067-077
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Comparative Evaluation of in Vitro Virulence of Mould Isolates from Clinical Cases and from Air Samples and Their Mortality Rates in Galleria mellonella Larvae
Zemfira ALİYEVA1, Hatice ERDEM1, Ahmet Kamil KARAKUŞ2, Ayşe KALKANCI1
1Gazi Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Ankara
2Gazi Üniversitesi Tıp Fakültesi, Dönem III, Ankara
Keywords: Galleria mellonella, air-borne moulds, pathogenic moulds, virulence

Objective: Air-borne moulds are the causative agents of oppurtunistic fungal infections. However limited number of in vitro and in vivo comparative studies have been performed about virulence features of these moulds. In this study, we compared the virulence features of different moulds isolated from patients and air samples.

Material and Methods: A total number of isolates from 12 clinical samples and 14 air-borne moulds were evaluated as for casein hydrolysis, phospholipase, esterase activities, DNAse production, esculin hydrolysis, catalase activity and aspartyl proteinase production. Galleria mellonella larvae were infected with these clinical and air-borne moulds. In vitro virulence factors and in vivo mortalities were compared.

Results: We found no difference between in vitro and in vivo virulence features of the moulds isolated from different sources.

Conclusion: The projections of this study on human infections should be evaluated.


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