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2017, Cilt 47, Sayı 3, Sayfa(lar) 125-130
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In vitro Daptomycin and Linezolid Susceptibility Profiles of Enterococcus faecium and Enterococcus faecalis Strains Isolated from Blood Cultures
Duygu ÖCAL, Oğuz Alp GÜRBÜZ, Zeynep DANSUK, Esra AKKAN KUZUCU, Enes ALTUNAY, Nalan APAYDIN, Gül ERDEM
Sağlık Bilimleri Üniversitesi Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi, Tıbbi Mikrobiyoloji Bölümü, Ankara
Keywords: Daptomycin, enterococcus, linezolid

Objective: Enterococcal infections are among the leading causes of health care-associated infections, and in the treatment of these infections gradually increasing rate of antimicrobial resistance issue is encountered all over theworld. Resistance to glycopeptides and high-level aminoglycosides also increases the use of antibiotics such as linezolid and daptomycin against resistant gram-positive bacteria. Detection of in vitro efficacies of daptomycin and linezolid against Enterococcus faecium and Enterococcus faecalis strains isolated from blood cultures was aimed in this study.

Material and Methods: Sevety-nine Enterococcus spp. isolated from blood cultures between May 2015-August 2016 were included in the study. Conventional methods and Phoenix automated system (Becton Dickinson, USA) were used in the identification of isolates. Broth microdilution was used to test for daptomycin susceptibility whereas gradient test was used to test linezolid susceptibility. Results were evaluated according to CLSI 2016 for daptomycin and EUCAST 2016 for linezolid.

Results: Twenty-four (30.4%) of the enterococci isolated from blood cultures were identified as E. faecium, and 55 (69.6%) as E. faecalis. All isolates were detected as susceptible to daptomycin and linezolid. Daptomycin MIC values were detected as 0.006-1 μg/ml for E. faecalis and 0.125-2 μg/ml for E. faecium. Linezolid MIC values were detected as 0.25-2 μg/ml for E. faecalis and 0.125-2 μg/ml for E. faecium.

Conclusion: Daptomycin and linezolid, as detected in vitro effective against Enterococci strains, are thought to be good alternatives in the treatment of resistant enterococcal infections. Although daptomycin and linezolid resistant strains were not detected in our study, microbiology laboratories should be careful about the possibility of development of resistance against these antibiotics.


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