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2017, Cilt 47, Sayı 4, Sayfa(lar) 197-204
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Microbiologic and Demographic Evaluation of Extrapulmonary Tuberculosis Cases in Mersin Province
Gönül ASLAN1, Mahmut ÜLGER2, Nuran DELİALİOĞLU1, Zehra Feza OTAĞ1, Duygu DÜŞMEZ APA3, Gülden ERSÖZ4, Oğuz KÖKSEL5, Erdal DORUK6, Necdet KUYUCU7, Cengiz ÖZCAN8, Gürol EMEKDAŞ9
1Mersin Üniversitesi Tıp Fakültesi Tıbbi Mikrobiyoloji Anabilim Dalı, Mersin
2Mersin Üniversitesi Eczacılık Fakültesi Farmasötik Mikrobiyoloji Anabilim Dalı, Mersin
3, Mersin Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı, Mersin
4Mersin Üniversitesi Tıp Fakültesi Klinik Bakteriyoloji ve Enfeksiyon Hastalıkları Anabilim Dalı, Mersin
sup>5Mersin Üniversitesi Tıp Fakültesi Göğüs Cerrahisi Anabilim Dalı, Mersin
6Mersin Üniversitesi Tıp Fakültesi Üroloji Anabilim Dalı, Mersin
7Mersin Üniversitesi Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Mersin
8Mersin Üniversitesi Tıp Fakültesi Kulak-Burun-Boğaz Hastalıkları Anabilim Dalı, Mersin
9Biruni Üniversitesi Tıp Fakültesi Tıbbi Mikrobiyoloji Anabilim Dalı, İstanbul
Keywords: Extrapulmonary tuberculosis, diagnosis, microscopic examination, culture

Objective: Mycobacterium tuberculosis causes disease by settling in various tissues and organs; and tuberculosis (TB) that has settled out of the lungs is called extrapulmonary tuberculosis (EPTB). In this study, we aimed to investigate the demographic features and distribution of organ and tissue localization of EPTB cases in our region which are all confirmed by culture positivity; and the comparison of diagnostic performance of the diagnostic methods.

Material and Methods: Clinical specimens of 2230 patients sent from various clinics, suspected of EPTB, were examined in the Department of Mycobacteriology. The presence of Mycobacterium tuberculosis complex (MTC) was evaluated by Ehrlich-Ziehl Neelsen and culture methods. Patients whose cultures demonstrated growth of MTC were evaluated retrospectively.

Results: Of the 2230 patients suspected of EPTB, MTC was isolated from cultures of 101 (4.5%) patients, and in 25 (1.1%) of them growth of acid-resistant bacilli was detected. Caseation necrosis was detected in 24 (68.6%) of 35 (34.7%) patients that had lymph node biopsy. The frequency of EPTB classified according to the sites of infection were as follows: TB lymphadenitis ( 34.7%), genitourinary system TB (19.8%), pleural TB (18.8%), bone and/or joint TB (12.9%), TB meningitis (10.9%), peritoneal TB (2%) and gastrointestinal system TB (1%).

Conclusion: The frequency of EPTB confirmed with culture positivity was found to be 4.5% in our region. Observation of the cases during the most productive age is important to show the extent of economic loss of our country. Delays in the diagnosis of EPTB cause problems in treatment of the disease with an increase in the mortality and morbidity.


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