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2018, Cilt 48, Sayı 2, Sayfa(lar) 134-140
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Attention! There is a Significant Increase in Trimetoprimsulfomethoxazole and Levofloxacin Resistance in Stenotrophomonas maltophilia Strains Isolated from Clinical Samples (2008-2016)
Gülşen HAZIROLAN1, Halime ARAZ2, Aysel KOCAGÜL ÇELİKBAŞ2, Neriman AKSU1
1Ankara Numune Eğitim ve Araştırma Hastanesi, Klinik Mikrobiyoloji̇ Kliniği, Ankara
2Ankara Numune Eğitim ve Araştırma Hastanesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, Ankara
Keywords: Stenotrophomonas maltophilia, antibiotic resistance, trimethoprim sulfamethoxazole, levofloxacin

Objective: As an health services-related infectious agent Stenotrophomonas maltophilia, is an opportunistic pathogen whose frequency and importance increase in intensive care units and immunocompromised patients. It is predominantly isolated from the blood, urine and respiratory tract specimens of the patients. Due to its intrinsic resistance to many antimicrobials, the treatment of the patients infected with S. maltophilia is very difficult. The aim of this study is to determine the resistance rates of trimethoprim sulfamethoxazole and levofloxacin of S. maltophilia strains isolated from various clinical samples within a period of eight years and the variation of these rates with respect to years. We discussed if it is sufficient to report only trimethoprim sulfamethoxazole resistance in terms of clinical follow-up and treatment as there is an increasing resistance to trimethoprim sulfamethoxazole.

Material and Methods: In our study, the distribution and antimicrobial susceptibility of 195 S. maltophilia isolates that were collected over an eight-year period were examined retrospectively. The identification and antibiotic susceptibility of the strains were examined using the Vitek2 Compact (BioMérieux, France), Matrix- Assisted Laser Desorption/Ionization time-of- flight, Mass Spectrometry (MALDI TOF MS, Bruker, Germany) system and the Phoenix (Becton Dickinson, USA) automatic devices.

Results: Most of the S. maltophilia strains were isolated mostly from respiratory tract samples (n=25). sent from intensive care units (n=63), The median rates of resistance against trimethoprim sulfamethoxazole, and levofloxacin were found to be 4.08% (0-13.58) and 11.71% (0-17.39, respectively. Seven strains had intermediate susceptibility to levofloxacin.

Conclusion: Considering the increase in antibiotic resistance over the years, restricted reporting of antibiotic susceptibility for a microorganism which has fewer treatment options creates difficulties for the clinicians. These strains should be kept for further study of their antibiotic susceptibilities.


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