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2018, Cilt 48, Sayı 2, Sayfa(lar) 134-140 |
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Attention! There is a Significant Increase in Trimetoprimsulfomethoxazole and Levofloxacin Resistance in Stenotrophomonas maltophilia Strains Isolated from Clinical Samples (2008-2016) |
Gülşen HAZIROLAN1, Halime ARAZ2, Aysel KOCAGÜL ÇELİKBAŞ2, Neriman AKSU1 |
1Ankara Numune Eğitim ve Araştırma Hastanesi, Klinik Mikrobiyoloji̇ Kliniği, Ankara 2Ankara Numune Eğitim ve Araştırma Hastanesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, Ankara |
Keywords: Stenotrophomonas maltophilia, antibiotic resistance, trimethoprim sulfamethoxazole, levofloxacin |
Objective: As an health services-related infectious agent
Stenotrophomonas maltophilia, is an opportunistic pathogen whose
frequency and importance increase in intensive care units and
immunocompromised patients. It is predominantly isolated from the
blood, urine and respiratory tract specimens of the patients. Due to
its intrinsic resistance to many antimicrobials, the treatment of the
patients infected with S. maltophilia is very difficult. The aim of this
study is to determine the resistance rates of trimethoprim
sulfamethoxazole and levofloxacin of S. maltophilia strains isolated
from various clinical samples within a period of eight years and the
variation of these rates with respect to years. We discussed if it is
sufficient to report only trimethoprim sulfamethoxazole resistance in
terms of clinical follow-up and treatment as there is an increasing
resistance to trimethoprim sulfamethoxazole.
Material and Methods: In our study, the distribution and antimicrobial susceptibility of 195 S. maltophilia isolates that were collected over an eight-year period were examined retrospectively. The identification and antibiotic susceptibility of the strains were examined using the Vitek2 Compact (BioMérieux, France), Matrix- Assisted Laser Desorption/Ionization time-of- flight, Mass Spectrometry (MALDI TOF MS, Bruker, Germany) system and the Phoenix (Becton Dickinson, USA) automatic devices. Results: Most of the S. maltophilia strains were isolated mostly from respiratory tract samples (n=25). sent from intensive care units (n=63), The median rates of resistance against trimethoprim sulfamethoxazole, and levofloxacin were found to be 4.08% (0-13.58) and 11.71% (0-17.39, respectively. Seven strains had intermediate susceptibility to levofloxacin. Conclusion: Considering the increase in antibiotic resistance over the years, restricted reporting of antibiotic susceptibility for a microorganism which has fewer treatment options creates difficulties for the clinicians. These strains should be kept for further study of their antibiotic susceptibilities. |
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