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2020, Cilt 50, Sayı 3, Sayfa(lar) 172-177
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Evaluation of Resistance Rates of Escherichia coli Isolates of Urinary Tract Infection to Various Antibiotics
Fatma Avcıoğlu, Mustafa Behçet
Bolu Abant İzzet Baysal Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Bolu
Keywords: Escherichia coli, antibiotic, resistance, urinary tract infection

Objective: Escherichia coli is the most common cause of urinary tract infections both in the world and in our country. Increase in bacterial resistance mechanisms also limit the treatment of these infections. Selection of antibiotics to be used according to an accurate antibiotic susceptibility test result is of great importance in controle of antibiotic resistance. We aimed to determine the susceptibility and resistance in E. coli, which is one of the pathogens in urinary tract infection in our hospital, to various antibiotics.

Method: Between 01.01.2018-01.11.2019, urine samples obtained from patients with an uncomplicated diagnosis of urinary tract infections, sent to the microbiology laboratory of our hospital, were analyzed retrospectively through the hospital archive. Fully automated device (Vitek2, bioMerieux, France) was used to identify bacteria in the urine culture and to determine antibiotic susceptibilities. Antibiotic susceptibility tests reults were interpreted according to minimal inhibitory concentrations in accordance with the European Committee on Antimicrobial Susceptibility Testing (EUCAST) 2018 standards.

Results: Out of a total of 22,774 urine samples, reproduction was detected in 1,962 (9%). Of these, 1466 (75%) were identified as E. coli. The analysis of the antibiotic susceptibility test results have indicated that isolates were resistant to ampicillin in 81%, gentamicin in 18%, trimethoprimsulfamethoxazole in 40%, nitrofurantoin in 4%, phosphomycin in 4%, amoxicillin-clavulanic acid in 46%, cefixime in 42%, ciprofloxacin in 41%, amikacin in 5%, imipenem in 2%.

Conclusion: In this study, it was understood that the use of ampicillin, amoxicillin clavulanic acid would not be appropriate, and phosphomycin and nitrofurantoin would be more appropriate in the treatment of urinary tract infections with the effect of E. coli.


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