2020, Cilt 50, Sayı 3, Sayfa(lar) 172-177 |
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Evaluation of Resistance Rates of Escherichia coli Isolates of Urinary Tract Infection to Various Antibiotics |
Fatma Avcıoğlu, Mustafa Behçet |
Bolu Abant İzzet Baysal Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Bolu |
Keywords: Escherichia coli, antibiotic, resistance, urinary tract infection |
Objective: Escherichia coli is the most common cause of urinary tract infections both in the world
and in our country. Increase in bacterial resistance mechanisms also limit the treatment of these
infections. Selection of antibiotics to be used according to an accurate antibiotic susceptibility test
result is of great importance in controle of antibiotic resistance. We aimed to determine the
susceptibility and resistance in E. coli, which is one of the pathogens in urinary tract infection in
our hospital, to various antibiotics.
Method: Between 01.01.2018-01.11.2019, urine samples obtained from patients with an
uncomplicated diagnosis of urinary tract infections, sent to the microbiology laboratory of our
hospital, were analyzed retrospectively through the hospital archive. Fully automated device
(Vitek2, bioMerieux, France) was used to identify bacteria in the urine culture and to determine
antibiotic susceptibilities. Antibiotic susceptibility tests reults were interpreted according to
minimal inhibitory concentrations in accordance with the European Committee on Antimicrobial
Susceptibility Testing (EUCAST) 2018 standards.
Results: Out of a total of 22,774 urine samples, reproduction was detected in 1,962 (9%). Of
these, 1466 (75%) were identified as E. coli. The analysis of the antibiotic susceptibility test results
have indicated that isolates were resistant to ampicillin in 81%, gentamicin in 18%, trimethoprimsulfamethoxazole
in 40%, nitrofurantoin in 4%, phosphomycin in 4%, amoxicillin-clavulanic acid
in 46%, cefixime in 42%, ciprofloxacin in 41%, amikacin in 5%, imipenem in 2%.
Conclusion: In this study, it was understood that the use of ampicillin, amoxicillin clavulanic acid
would not be appropriate, and phosphomycin and nitrofurantoin would be more appropriate in
the treatment of urinary tract infections with the effect of E. coli.
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