Cryptococcus neoformans is an encapsulated, opportunistic yeast species that can infect humans through inhalation and shows a preference for the central nervous system. This report presents a case of C. neoformans meningitis in an HIV-negative patient exhibiting various neurological symptoms, who also tested positive for autoimmune markers and was undergoing high-dose steroid therapy. In clinical cases due to C. neoformans is the causative agent, mortality rates are elevated when diagnosis is delayed.