2016, Cilt 46, Sayı 2, Sayfa(lar) 082-087 |
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Retrospective Investigation of ICD Codes of Patients with Dense-Fine Speckled (DFS) Pattern Antinuclear Antibodies |
Erhan KONGUR, Neşe KAKLIKKAYA, Gülçin BAYRAMOĞLU, Esra ÖZKAYA, Şükran ÖNDER, Rukiye AKYOL, Bünyamin KASAP |
Karadeniz Teknik Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Trabzon |
Keywords: Antinuclear antibody, DFS pattern, ICD codes |
Objective: Determination of the presence of antinuclear
antibodies (ANA) in systemic circulation has a key role in
diagnosis of many autoimmune diseases. However, it has
still not been clear whether dense fine speckled (DFS)
pattern of ANA, which are commonly found in indirect
immunofluorescence (IIF) screening tests indicating the
presence of anti-DFS70 antibodies, are related with the
diseases. The aim of this study was to investigate the
association between clinical diagnosis of patients with the
presence of DFS pattern of ANA.
Material and Methods: Two hundred patients with presence
of DFS pattern on ANA-IIF screening test were included in the
study. To obtain the clinical data of the patients, International
Statistical Classification of Diseases and Related Health
Problems (ICD) codes, which were determined by physicians
of the patients, were retrospectively analyzed.
Results: Of the patients with DFS pattern of ANA, 158
(79.0%) were women and 42 (21.0%) were men. These
antibodies were found most frequently in age range of 1-10
(58 patients, 29.0%), and the least in age range of 71-80
(one patient, 0.5%), and it was determined that the frequency
decreased as the age increased. Of the patients 26 (13.0%)
were diagnosed as systemic autoimmune rheumatic diseases
(SARD), eight (4.0%) as organ-specific autoimmune diseases,
nine (4.5%) as malignancy, and 127 (63.5%) were followedup
due to different diseases of various systems. No clinical
diagnosis was indicated in 30 (15.0%) patients.
Conclusion: As a result, although it could not be associated
with a specific disease, DFS pattern of ANA may be
positive in SARD. Therefore, it is concluded that the
patients with DFS pattern of ANA should be evaluated
together with clinical findings.
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