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2016, Cilt 46, Sayı 2, Sayfa(lar) 082-087
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Retrospective Investigation of ICD Codes of Patients with Dense-Fine Speckled (DFS) Pattern Antinuclear Antibodies
Erhan KONGUR, Neşe KAKLIKKAYA, Gülçin BAYRAMOĞLU, Esra ÖZKAYA, Şükran ÖNDER, Rukiye AKYOL, Bünyamin KASAP
Karadeniz Teknik Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Trabzon
Keywords: Antinuclear antibody, DFS pattern, ICD codes

Objective: Determination of the presence of antinuclear antibodies (ANA) in systemic circulation has a key role in diagnosis of many autoimmune diseases. However, it has still not been clear whether dense fine speckled (DFS) pattern of ANA, which are commonly found in indirect immunofluorescence (IIF) screening tests indicating the presence of anti-DFS70 antibodies, are related with the diseases. The aim of this study was to investigate the association between clinical diagnosis of patients with the presence of DFS pattern of ANA.

Material and Methods: Two hundred patients with presence of DFS pattern on ANA-IIF screening test were included in the study. To obtain the clinical data of the patients, International Statistical Classification of Diseases and Related Health Problems (ICD) codes, which were determined by physicians of the patients, were retrospectively analyzed.

Results: Of the patients with DFS pattern of ANA, 158 (79.0%) were women and 42 (21.0%) were men. These antibodies were found most frequently in age range of 1-10 (58 patients, 29.0%), and the least in age range of 71-80 (one patient, 0.5%), and it was determined that the frequency decreased as the age increased. Of the patients 26 (13.0%) were diagnosed as systemic autoimmune rheumatic diseases (SARD), eight (4.0%) as organ-specific autoimmune diseases, nine (4.5%) as malignancy, and 127 (63.5%) were followedup due to different diseases of various systems. No clinical diagnosis was indicated in 30 (15.0%) patients.

Conclusion: As a result, although it could not be associated with a specific disease, DFS pattern of ANA may be positive in SARD. Therefore, it is concluded that the patients with DFS pattern of ANA should be evaluated together with clinical findings.


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