2016, Cilt 46, Sayı 4, Sayfa(lar) 165-171 |
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Resistance Rates of Mycobacterium tuberculosis Complex Strains to the Primary Anti-tuberculosis Drugs in Konya Province, Turkey |
Fatma ESENKAYA TAŞBENT1, Metin DOĞAN2 |
1Konya Halk Sağlığı Laboratuvarı, Konya 2Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Konya |
Keywords: Mycobacterium tuberculosis, antituberculosis susceptibility, resistance |
Objective: In this study we aimed to retrospectively analyse
primary anti-tuberculosis drug susceptibilities of
Mycobacterium tuberculosis complex strains, isolated from
patients with initial diagnosis of tuberculosis during the
two years period between 2014 and 2015 at our
laboratory.
Material and Methods: Clinical samples obtained from
patients with suspected tuberculosis were stained with
Ehrlich-Ziehl-Neelsen method and evaluated microscopically.
After processing of samples, each sample was inoculated
onto Löwenstein-Jensen medium and automated culture
system (Mycolor TK, Salubris A.Ş., Istanbul) medium. If
bacterial growth was detected, Mycobacterium tuberculosis
complex typing was made and if requested antituberculosis
drug susceptibilities for streptomycin, isoniazid, rifampicin
and ethambutol were tested.
Results: Out of 5406 clinical samples sent to the laboratory, a
total of 266 Mycobacterium tuberculosis complex iolates were
included in the study and only single sample from each patient
was processed. Total resistance rates to streptomycin, isoniazid,
rifampicin, and ethambutol were 4.5%, 6.4%, 9% ve 4.5%,
respectively. Among antimycobacterial drugs, the highest
resistance rate was found for rifampicin and 83.1% of the
patients were susceptible to all of the agents tested. Multidrug
resistance was determined as 2.6 percent. In the study,
automated culture system was also evaluated in comparison
with Ehrlich-Ziehl-Neelsen staining method.
Conclusion: Monitoring of resistance patterns in
tuberculosis is important in determining treatment protocols
and will also be useful in preventing the development of
resistance in long term.
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