2017, Cilt 47, Sayı 1, Sayfa(lar) 011-020 |
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Relationship Between Pegylated Interferon-Ribavirin Treatment Response and Chemokine Ligand and Receptor Levels in Hepatitis C Virus Infected Patients |
Orçun ZORBOZAN1, İlknur KALELİ1, Hüseyin TURGUT2 |
1Pamukkale Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Denizli 2Pamukkale Üniversitesi Tıp Fakültesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Denizli |
Keywords: Delta 32, chemokines, host-virus interactions |
Objective: Antiviral agents used in chronic HCV infection
treatment have serious side effects. HCV-RNA is used to
evaluate treatment response. HCV genotype is used for
determining duration and dose of treatment but there is no
definite predictor of treatment response yet. This study is
designed to investigate the relationship between chemokines,
chemokine receptors, delta-32 deletion and HCV infection
treatment response.
Material and Methods: Fifty chronic HCV-infected patients
and 28 healthy controls were included in the study . Serum
CCL3, CCL4, CCL5, CXCL9 and CXCL10 levels were
measured by commercial ELISA kits. CCR5 and CXCR3
surface expressions of peripheral blood CD8+ cells were
evaluated by flow-cytometry. Delta-32 deletions were
evaluated by real-time PCR.
Results: Patients were divided into two groups according to
their treatment responses. In both of the patient groups,
percentages of CCR5+-CD8+ lymphocytes and CXCR3+-
CD8+ lymphocytes were higher than those of the control
(p=0.001, p=0.021, respectively); but there was no significant
difference between patient groups (p=0.872). CCL3, CXCL9
and CXCL10 levels were significantly higher in patient groups
than those of the control. CCL4 and CCL5 levels were not
significantly different among responders, non-responders and
contro subjectsl. CCL3, CCL4, CCL5 and CXCL9 levels were
not significantly different between responder and nonresponder
patients, while CXCL10 levels in non-responders
were higher than those of responders (p=0.001).
Conclusion: According to the findings of this study, CCR5
and CXCR3 surface expressions of CD8+ cells in the
peripheral blood increased in chronic hepatitis C but there
was no difference between responder and non-responder
patient groups; CCL3, CXCL9 and CXCL10 levels increased
in HCV infection, however, only CXCL10 predicted the
treatment response.
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