2017, Cilt 47, Sayı 2, Sayfa(lar) 067-077 |
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Comparative Evaluation of in Vitro Virulence of Mould Isolates from Clinical Cases and from Air Samples and Their Mortality Rates in Galleria mellonella Larvae |
Zemfira ALİYEVA1, Hatice ERDEM1, Ahmet Kamil KARAKUŞ2, Ayşe KALKANCI1 |
1Gazi Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Ankara 2Gazi Üniversitesi Tıp Fakültesi, Dönem III, Ankara |
Keywords: Galleria mellonella, air-borne moulds, pathogenic moulds, virulence |
Objective: Air-borne moulds are the causative agents of
oppurtunistic fungal infections. However limited number of
in vitro and in vivo comparative studies have been
performed about virulence features of these moulds. In this
study, we compared the virulence features of different
moulds isolated from patients and air samples.
Material and Methods: A total number of isolates from 12
clinical samples and 14 air-borne moulds were evaluated
as for casein hydrolysis, phospholipase, esterase activities,
DNAse production, esculin hydrolysis, catalase activity
and aspartyl proteinase production. Galleria mellonella
larvae were infected with these clinical and air-borne
moulds. In vitro virulence factors and in vivo mortalities
were compared.
Results: We found no difference between in vitro and in
vivo virulence features of the moulds isolated from different
sources.
Conclusion: The projections of this study on human
infections should be evaluated.
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