2018, Cilt 48, Sayı 1, Sayfa(lar) 001-013 |
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Bacterial Biofilms: Detection Methods and Role in Antibiotic Resistance |
Aybala TEMEL, Bayrı ERAÇ |
Ege Üniversitesi Eczacılık Fakültesi, Farmasötik Mikrobiyoloji Anabilim Dalı, İzmir |
Keywords: Biofilm, biofilm detection, antibiotic resistance |
Biofilms are micro-ecosystems that can occur on medical
devices and biomaterials, or on host epithelial cells and
mucosal surfaces, and play a role in many different diseases.
Methods for determining the formation of biofilm are very
important for preventing biofilm infections. Since
colorimetric methods which are frequently used to detect
biofilm formation have various disadvantages, there is a
need for standard, rapid and reliable methods. Various new
technologies have been developed that can also be used for
biofilm detection. Among these; real-time cell analysis
method that detects the change in resistance to electric
current, fiber-optic sensor method in which the change
in penetration of infrared rays is measured, and
luminescent conjugated oligothiophene method based
on detecting biofilm matrix components are promising.
With these methods, the structure of biofilm can be
determined more sensitively, quickly and quantitatively.
In addition to the antibiotic resistance of planktonic bacteria,
resistance that results from the biofilm structure, further
complicates treatment of biofilm infections. It is thought that
the biofilm resistance is a multifactorial event and multiple
mechanisms occur simultaneously. In this review, the
formation of bacterial biofilms and factors affecting them,
biofilm detection methods, biofilm infections and factors that
play a role in biofilm resistance are examined.
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