2018, Cilt 48, Sayı 1, Sayfa(lar) 052-059 |
[ Türkçe Özet ]
[ PDF ]
[ Benzer Makaleler ]
|
A Research on the Anthrax Agent and Its Seroprevalance in the Eastern Anatolia Region |
Çiğdem Eda BALKAN1, Selahattin ÇELEBİ2 |
1Kafkas Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Kars 2Atatürk Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Erzurum |
Keywords: Bacillus anthracis, seroprevalence, protective antigen |
Objective: Anthrax, is a lethal bacterial zoonosis transmitted
through skin, inhalation or gastrointestinal tract, and
spread by herbivorous animals particularly with cattle and
sheep. One of the fundamental virulence factors of Bacillus
anthracis is its toxins consisting of protective antigen (PA),
edema factor and lethal factor. The protective antigen is
especially responsible for intracellular entrance of the
other two factors. The aim of the present study is to
investigate the protective antigen in blood samples of
patients who applied to the hospitals in our region with a
suspected anthrax infection, and to determine the prevalence
in the region.
Material and Methods: ELISA (Enzyme Linked
Immunosorbent Assay, Biosource, USA) method was used
in the study in order to detect the presence of the protective
antigen IgG antibody.
Results: We determined 35 Bacillus anthracis protective
antigen IgG positive results out of 47 samples taken from
patients suspected of anthrax in Ataturk University Yakutiye
Training and Research Hospital and Erzurum Regional
Training and Research Hospital. Thirty-five (6 female:
17%, and 29 male:82.8%) patients had positive results.
Out of 35 patients 27 (77.1%) were into animal husbandry,
8 patients (22.8%) were not involved in animal husbandry
but had a history of contact with animal flesh.
Conclusion: We have attributed the results obtained from
the samples taken from patients, who had clinical findings
of anthrax but without protective antigens in their blood to
medical treatments they received in various health institutes
before they applied to our hospital, to random use of
antibiotics relying on the common tendency that antibiotics
can cure any disease, impairment of toxin-producing
ability of the bacteria, drawal of blood samples when
protective antigen levels in the circulation decreased to
undetectible levels.
|
[ Türkçe Özet ]
[ PDF ]
[ Benzer Makaleler ]
|