2018, Cilt 48, Sayı 1, Sayfa(lar) 072-077 |
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Evaluation of RPR, TPHA Test Results and Diagnostic Algorithms Used in Syphilis Diagnosis |
Cemile SÖNMEZ |
Halk Sağlığı Genel Müdürlüğü, Sağlık Bakanlığı, Ankara |
Keywords: Treponema pallidum, syphilis, sexually transmitted diseases, algorithms |
Objective: Despite the fact that syphilis reporting is
mandatory in our country, it is difficult to predict the actual
frequency of the disease due to the problems in the
notification system. RPR or rapid test positive sera sent to
our center for confirmation, were tested by RPR and TPHA
tests again. In this study it is aimed to evaluate the
conventional and reverse algorithms used in syphilis
diagnosis in terms of obtained data.
Material and Methods: The results of serum samples from
362 patients who had positive RPR or rapid test results and
were sent to our center for confirmation between January
2014-November 2017 were re-evaluated. Conventional and
reverse algorithms were analyzed retrospectively. SPSS
version 23.0 package program was used for statistical
analysis.
Results: Out of 362 suspected syphilis patients 147 (40.6%)
RPR negative and TPHA positive; 6 (1.7%) RPR positive
and TPHA negative. 173 (47.8%) RPR and TPHA positive
patients were detected. When the distribution of both RPR
and TPHA positivities was determined according to the
years, the highest positivity was observed in the year 2017.
In the conventional algorithm, 173 patients were positive
and six were false positive. In the reverse algorithm, 311
patients were positive and nine were false positive.
Conclusion: As a result, it was determined that the number
of syphilis positive cases mostly increased in the year 2017.
In the case of suspicious patients, it is concluded that the
reverse algorithm will contribute to the increase in the
diagnostic capacity of syphilis.
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