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2022, Cilt 52, Sayı 1, Sayfa(lar) 056-062
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Seroprevalence of Cytomegalovirus (CMV) IgG and IgM Antibodies in Pregnant Women in Izmir: An Analysis of CMV IgG Avidity Tests
Bilal Olcay Peker1, Tuba Müderris2, Süreyya Gül Yurtsever2, Selçuk Kaya2
1İzmir Kâtip Çelebi Üniversitesi Atatürk Eğitim ve Araştırma Hastanesi, Tıbbi Mikrobiyoloji Laboratuvarı, İzmir, Türkiye
2İzmir Kâtip Çelebi Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Ana Bilim Dalı, İzmir, Türkiye
Keywords: CMV, pregnancy, CMV avidity

Objective: We aimed to determine the seroprevalence of cytomegalovirus (CMV) in pregnant women in İzmir province and to evaluate CMV IgG antibody levels and CMV avidity test results according to years.

Methods: CMV IgM, CMV IgG and CMV IgG avidity tests were performed using the chemiluminescence microparticle immunoassay method in serum samples from pregnant women(≥18 years, ≤20 gestational week) at the microbiology laboratory of university hospital from January 2016 to December 2019 and results were retrospectively analyzed.

Results: The mean age of 3062 pregnant women included in the study was 28.57±5.96(range: 18 - 48 years) years. The CMV IgG and IgM seropositivity rates were 94.22% (n=2885) and 1.37% (n=42), respectively. CMV IgG avidity index was low in three patients with CMV IgM positive (7.14%, n=3). A weak correlation was found between IgG antibody level and age of CMV seropositive pregnant women (p=0.041, ρ=0.038, r2: 0.001). Although the rate of CMV IgG seropositivity changes according to the year, it was lowest (83.22%) in 2016, and CMV IgM positivity was highest in 2019 (2.13%). CMV seropositivity was highest in pregnant women aged 38 - 48 years and CMV IgG levels were significantly lower in this group according to age (p=0.004).

Conclusion: In the study, CMV IgG seroprevalence (94.22%) is high among pregnant women in Izmir, but the presence of seronegative and CMV IgM positive pregnant women show that there are still risk pregnancies in terms of congenital CMV infection. With the establishment of an effective national surveillance network, additional measures can be applied in the follow-up of pregnant women by expanding the scope of seroprevalence studies with continuously updated data by region and year.


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