Chryseobacterium indologenes is a gram-negative, non-fermentative bacillus that causes opportunistic infections, especially in the newborns and immunocompromised patients. This bacterium, which is resistant to chlorination, creates a potential source of infection by contaminating respirators, intubation tubes and humidifiers in the hospital. In the literature, there are studies reporting Chryseobacterium indologenes as a causative agent of bacteremia, ventilator-associated pneumonia, meningitis, peritonitis, endocarditis, pyelonephritis and lumboperitoneal shunt infection. Studies have reported that this bacterium was resistant to antibiotics, such as carbapenems, cephalosporins and aminoglycosides. Also, the susceptibility rates of trimethoprim sulfamethoxazole, ciprofloxacin and piperacillin tazobactam were also found to be high, and it was emphasized that the most appropriate antibiotics for treatment may be the new quinolones, such as levofloxacin and gatifloxacin. Levoloxacin is an antibiotic used in the treatment of ventilator-associated pneumonia caused by multidrug-resistant microorganisms, as it reaches high concentrations in the lung tissue and respiratory secretions. Although there are limited data about the use of levofloxacin in newborns, there are studies that show clinical success when used in appropriate dose and duration. In this case report, C. indologenes isolated as a causative agent of ventilator-associated pneumonia in a newborn with cerebral palsy and its antibiotic resistance is presented.