Leishmaniasis is a zoonotic infection that occurs as a result of the bite of the female sandflies. Clinically, it manifests in visceral (VL), cutaneous (CL) or mucocutaneous (MCL) forms. In our country, CL is more common than VL. After receiving a large number of Syrian immigrants to our province, the disease, which was sporadically seen, is now seen in all cities. Diagnosis and treatment of cutaneous leishmaniasis are difficult in immunocompromised patients. Pancreatitis and nephrotoxicity are commonly seen as side effects of drugs in organ transplant patients. In this case, a reactive multiple lesion and ulcerated CL case is presented in a 62-yearold male Syrian patient who had renal transplant, encountered for the first time in our region. The patient was treated with liposomal amphotericin B and meglumine antimoniate. It is emphasized that CL should not be overlooked in patients living in endemic areas and undergoing organ transplantation.