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2012, Cilt 42, Sayı 2, Sayfa(lar) 055-060
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Antibiotic Resistance Profiles of Acinetobacter baumannii Strains Isolated from Various Clinical Specimens
1Kafkas Üniversitesi Tıp Fakültesi Tıbbi Mikrobiyoloji Anabilim Dalı, Kars
2Süleyman Demirel Üniversitesi Tıp Fakültesi Tıbbi Mikrobiyoloji Anabilim Dalı, Isparta
Keywords: Acinetobacter baumannii, multidrug resistant

Objective: In this study it was aimed to determine the distribution of 237 Acinetobacter baumannii strains according to specimen type and clinics they were obtained from and resistance rates of these strains against various antimicrobial agents.

Materials and Methods: The strains were isolated from various clinical samples of patients hospitalized in Süleyman Demirel University Hospital, Isparta, Turkey between June 2009 and July 2011. The samples were inoculated onto MacConkey agar and 5% sheep blood agar and A. baumannii isolates were identified by using conventional methods and automated bacterial identification system (BBL Crystal Identification Systems, BD, USA). Antimicrobial susceptibility tests were carried out by the Kirby-Bauer disc diffusion method using Mueller-Hinton agar (Oxoid, England) according to the recommendations of Clinical and Laboratory Standards Institute (CLSI).

Results: Most of the isolates were obtained from patients hospitalized in the intensive care units (61.6 %) which were mostly respiratory tract specimens (48.2%). Cefepime (99.6 %), cefotaxime (99.6 %) and ceftazidime (98.7%) had the highest rates of resistance while imipenem (60.8%) and meropenem (71.7%) had the lowest rates of resistance. A total of 114 isolates (48.1%) were found to be resistant to both of the carbapenems and out of these 114 isolates 86 (75.4%) were resistant to all of the antimicrobials tested. Compared to the strains sensitive to only one carbapenem or both of the carbapenems, the resistance rates of carbapenem resistant strains were statistically higher for ampicillin/sulbactam, gentamicin, ciprofloxacin and trimetoprim/sulphamethoxazol.

Conclusion: It was concluded that A. baumannii isolates had high rates of resistance to several antimicrobial agents used in therapy and especially isolates showing carbapenem resistance tended to be multi-drug resistant. When pan-resistant A. baumannii strains are taken into consideration, it is obvious that organisation of the therapy according to the antibiotic susceptibility testing of A.baumannii isolates is a necessity to prevent serious treatment failures in A. baumannii infections. Furthermore, hospitals should be compelled to develop their own antibiotic policies based on local patterns of resistance.

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