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2013, Cilt 43, Sayı 2, Sayfa(lar) 039-044
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Toxoplasma and Schizophrenia
Nuran KARABULUT
Elazığ Ruh Sağlığı ve Hastalıkları Hastanesi, Mikrobiyoloji Laboratuvarı, Elazığ
Keywords: Toxoplasma gondii, schizophrenia, antipsychotic drugs

Schizophrenia which is a global serious neuropsychiatric disorder of unknown etiology. The possible association between infectious agents and schizophrenia has been widely discussed in recent studies. Most of these studies have been focused on T. gondii and many of them supported the hypothesis that T. gondii infection might be an etiological factor for the development of schizophrenia. A large number of current studies have reported that a wide spectrum of patients with schizophrenia developed antibodies to T. gondii. Neuropathological studies have shown that T. gondii have an in vitro selective effect on neurons, glial cells and particularly on astrocytes. It has been shown that toxoplasmas may affect levels of dopamine, norepinephrine, and other neurotransmitters as in the individuals with schizophrenia. It has also been reported that antipsychotic drugs known to be effective in schizophrenia, also inhibit T. gondii. In this review, data about the relationship between T. gondii and the central nervous system, prevalence of antibodies to T. gondii in schizophrenics and antiprotozoal effects of antipsychotic drugs will be analyzed in the light of recent literature.

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