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2015, Cilt 45, Sayı 2, Sayfa(lar) 088-091 |
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Investigation of Fosfomycin Trometamol Susceptibility in Escherichia coli Strains Isolated from Urinary Tract Infections |
Arzu İRVEM1, Eyüp Veli KÜÇÜK2, Emin PALA3, Şenol ÇOMOĞLU4, Behiye DEDE4, Gül KARAGÖZ4, F.Muhterem YÜCEL1 |
1Sağlık Bilimleri Üniversitesi Ümraniye Eğitim ve Araştırma Hastanesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Bölümü, İstanbul 2Sağlık Bilimleri Üniversitesi Ümraniye Eğitim ve Araştırma Hastanesi, Üroloji Bölümü, İstanbul 3Sağlık Bilimleri Üniversitesi Ümraniye Eğitim ve Araştırma Hastanesi, Aile Hekimliği Bölümü, İstanbul 4Sağlık Bilimleri Üniversitesi Ümraniye Eğitim ve Araştırma Hastanesi, Enfeksiyon Hastalıkları Bölümü, İstanbul |
Keywords: Escherichia coli, fosfomycin trometamol, urinary system |
Objective: Escherichia coli is the most common
microorganism isolated from both community and
hospital-acquired urinary tract infections. In our study, it
was aimed to investigate the extended spectrum beta
lactamase (ESBL) positivity and fosfomycin trometamol
(FT) resistance rates in E. coli strains isolated from urine
cultures sent to microbiology laboratory of our hospital.
Materials and Methods: The identification and antibiotic susceptibility testing of the bacteria considered to be uropathogenic in the urine cultures investigated in microbiology laboratory of our hospital between 2012 and 2013 were performed with VITEK 2 (BioMérieux, France) automated system. FT resistance and ESBL positivity were evaluated retrospectively in 1085 E. coli strains isolated. Results: Three hundred and three of 1085 E. coli strains studied were determined to be ESBL positive (27.9%) and 782 ESBL negative. Fifteen (1.38 %) E. coli strains were resistant to FT, while 1070 E. coli strains were susceptible to FT is 1070. The difference between susceptibilities of ESBL positive and ESBL negative strains to fosfomycin was not found to be statistically significant (p>0.05). Conclusion: In our study, FT resistance was found to be low which is compatible with other studies and also was found to have no relation with ESBL resistance. This can be explained with low level of resistance to FT, the chemical structure and different target regions of the drug compared with other antimicrobial agents and the absence of cross-resistance. |
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