2018, Cilt 48, Sayı 3, Sayfa(lar) 199-204 |
[ Türkçe Özet ]
[ PDF ]
[ Benzer Makaleler ]
|
The Frequency and Genotype Distribution of Human Papillomavirus in Cervical Specimens in Sivas Region |
Mürşit HASBEK, Cem ÇELİK, Aslı ÇABUK, Mustafa Zahir BAKICI |
Cumhuriyet Üniversitesi Tıp Fakültesi Tıbbi Mikrobiyoloji Anabilim Dalı, Sivas |
Keywords: Cervical cancer, HPV DNA, genotype |
Objective: Human Papillomavirus (HPV) contains a
double-stranded circular DNA virus which belongs to the
papillomaviridae family. It has been shown that it was
found in 99.7% of cervical cancers. Different prevalence
rates have been reported in studies conducted in our
country and in different regions of the world. Our study
aimed to determine the prevalence and the genotype
distribution of HPV in our region.
Material and Methods: In this study, HPV DNA positivity of
cervical specimens of women who applied to the outpatient
clinic of Obstetrics and Gynecology, Cumhuriyet University
Research and Application Hospital, between January 2015
and December 2017 were investigated. A total of 368 women
aged between 14-83 years were included in this study.
Reverse hybridization and PCR techniques were used. Data
in our study were obtained retrospectively.
Results: HPV DNA positivity was 28.8% (n = 106) in 368
samples included in this study. The most common genotype
was high- risk HPV genotype 16 (23.5%). The HPV DNA
positivity in women under 30 years of age was statistically
significantly higher than women over 30 years (p = 0.009).
Conclusion: In order to determine the HPV prevalence in
our country accurately, there is a need for multi-centered
studies with larger standardized patient and control groups.
|
[ Türkçe Özet ]
[ PDF ]
[ Benzer Makaleler ]
|