2019, Cilt 49, Sayı 1, Sayfa(lar) 001-010 |
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The Relationship Between Tuberculosis and TLR Gene Polymorphisms |
Reika Dilara Vaizoğlu, Ceren Acar |
İnönü Üniversitesi Fen-Edebiyat Fakültesi Moleküler Biyoloji ve Genetik Bölümü, Malatya, Türkiye |
Keywords: Tuberculosis, TLR, genotyping |
Tuberculosis, one of the major health problems in the world, causes many deaths every year.
According to the 2018 World Health Organization (WHO) report, 6.7 million new tuberculosis
cases were reported in 2017. The disease can remain in the latent phase for a very long time after
infecting the affected individual. While some of the infected people contract the disease, while
the others never develop the disease; even about 90% of the contracted people improve and get
well by the immune systems response. As in many infectious diseases, the difference between the
number of infected people and the number of people with the disease is due differences in
balance between the host defense and the virulence of the organism. In the studies conducted;
this difference was mostly attributed to the state of the immune system of the host, but this is not
accepted as an adequate response. With these terms, the genetic basis of the response to
infectious agents needs to be investigated in order to understand the relationship between
infectious diseases and the host. In this review we have summarized the studies on the effect of
polymorphisms of TLR genes which are involved in the immune response and the susceptibility to
Mycobacterium tuberculosis.
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