2019, Cilt 49, Sayı 3, Sayfa(lar) 147-153 |
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The Distribution of Species and Antifungal Susceptibilities of Yeasts Isolated from Various Postmortem Samples |
Nihan Ziyade1, Neval Elgörmüş1, Murat Nihat Arslan2 |
1İstanbul Adli Tıp Kurumu, Postmortem Mikrobiyoloji Laboratuvarı, İstanbul 2İstanbul Adli Tıp Kurumu, Otopsi Şubesi, İstanbul |
Keywords: Candida species, antifungal susceptibility, post-mortem microbiology |
Objective: Fungal infections caused by Candida species are important causes of morbidity
and mortality in immunocompromised patients, especially in cases requiring prolonged stay
in the intensive care units. In our study, it was aimed to determine the distribution of species
and antifungal susceptibility of Candida species isolated from various postmortem
samples.
Method: Between the years 2014-2018, a total of 176 yeast species grown in various body
samples of 71 autopsized cases sent to the Postmortem Microbiology Laboratory for
examination were included in this retrospectiive study. Isolated yeast species were
identified, and typed by colony morphology, Gram staining properties, germ tube test and
VITEK 2 Compact® (bioMérieux, France) automated identification system. Antifungal
susceptibilities were determined by VITEK 2 Compact® system.
Results: A total of 176 yeast isolates were identified as follows: 87 (49.4%) Candida albicans,
36 (20.5%) Candida tropicalis, 30 (17%) Candida glabrata, 8 (4.5%) Candida parapsilosis, 6
(3.4%) Candida kefyr, 5 (2.8%) Candida krusei, 2 (1.2%) Candida dubliniensis, and 2 (1.2%)
Cryptococcus neoformans. The resistance rates of the isolates against fluconazole, voriconazole,
amphotericin B and micafungin were 10.2%, 4.1%, 0% and 100%, respectively.
Conclusion: Microbiological researches concerning invasive fungal infections in forensic
autopsies are rarely performed. For this reason, antifungal susceptibility and species
identification of Candida in postmortem cases will contribute to national and international
forensic microbiological studies.
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