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2021, Cilt 51, Sayı 3, Sayfa(lar) 271-275
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Comparison of QuantiFERON-TB GOLD Test and Tuberculin Skin Test in Patients Investigated for the Presence of Latent Tuberculosis Infection
İmge Say1, Burak Küçük1, Filiz Orak1, Murat Aral1, Adem Doğaner2
1Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Kahramanmaraş, Türkiye
2Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi, Biyoistatistik ve Tıbbi Bilişim Anabilim Dalı, Kahramanmaraş, Türkiye
Keywords: Latent tuberculosis, tuberculin skin test, quantiferon

Objective: In this study, we aimed to determine the diagnostic value of the tuberculin skin test (TST) and the QuantiFERON-TB Gold Plus (QFT-Plus) test in the diagnosis of latent tuberculosis infection and to compare the effectiveness of these two tests.

Method: One hundred and thirty- four patients aged between 5 and 80 with suspect tuberculosis having QuantiFERON-TB GOLD Plus test and Tuberculin skin test results were included in our study between January 2018 and February 2019.

Results: A total of 134 patients aged between 5-80 years were included in the study. In 26 of the QFT-Plus positive cases, TST was positive and in 17 of them TST were negative. TST was positive in 64 patients. Twenty six of TST positive patients were found to be QFT-Plus positive and 38 of them were QFT-Plus negative. The distributional difference was found to be statistically significant. There was no agreement between the QFT-Plus and TDT tests.

Conclusion: As a result, considering that TST, which is still used routinely today, has some disadvantages in LTBI research, it is thought that QFT-Plus test can be used as an alternative despite its high cost.


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