2022, Cilt 52, Sayı 2, Sayfa(lar) 095-102 |
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Investigetion of Carbapenem Resistance Ratio Changes and Resistange Genes in Clinical Isolates of Klebsiella pneumoniae Between 2012 to 2020 |
Murat Telli |
Aydın Adnan Menderes Üniversitesi, Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Aydın, Türkiye |
Keywords: Klebsiella pneumoniae, resistance of carbapenems, carbapenemase |
Objective: Infections due to carbapenem-resistant Klebsiella pneumoniae has been a serious problem in our
country and the world. Carbapenem resistance occurs in several mechanism, where the most common one is
the production of carbapenemase enzyme. The aim of this study is to investigate the changes in resistance ratio
and resistance mechanism in our hospital between 2012 to 2020.
Methods: Carbapenem resistant strains that has been detected in K. pneumoniae strains isolated from several
clinical samples were included in this study. KPC, OXA-48, NDM, IMP and VIM resistance genes were investigated
by polymerase chain reaction.
Results: A total of 291 (7.5%) carbapenem-resistant K. pneumoniae isolates were identified between 2012 and
2020. The distribution of the resistant genes of strains was as follows: strains with single genes: OXA-48, NDM-
1, KPC and VIM were 113 (38.8%), 32 (11.0%), 7 (2.4%) and 5 (1.7%), respectively. Strains with multiple genes
were identified as follows: OXA-48+NDM was 123 (42.3%), OXA-48+KPC was 2 and one strain of each for OXA-
48+VIM, NDM+KPC, NDM+IMP.
Conclusion: The ratio of carbapenem-resistant K. pneumoniae strains was found to be elevated in our
hospital. OXA-48 resistance gene was the most prevalent (38.8%) single gene, followed by NDM resistance
genes. In addition, coexistence of OXA-48+NDM (42.3%) genes was the most prevalent resistance mechanism
in our hospital. Therefore, continious screening of resistance in KDKp strains, and investigation of resistance
mechanisms in local and national studies are highly important in the treatment of infections due to these
bacteria and control of resistance.
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