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2022, Cilt 52, Sayı 3, Sayfa(lar) 202-207
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Investigation of the Role of Herpes Simplex Virus-1, Herpes Simplex Virus-2 and Chlamydia trachomatis in the Etiology of Recurrent Aphthous Stomatitis
Cem Baysal1, Mustafa Önel2, Emel Bozkaya2, Şükrü Şirin1, Ali Ağaçfidan2
1İstanbul Üniversitesi, Diş Hekimliği Fakültesi, Oral Diagnoz ve Radyoloji Anabilim Dalı, İstanbul, Türkiye
2İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, İstanbul, Türkiye
Keywords: Recurrent aphthous stomatitis, herpes simplex virus, chlamydia trachomatis

Objective: Recurrent aphthous stomatitis(RAS) is one of the most common ulcerative diseases of the oral mucosa.Herpes Simplex Virus(HSV) has been shown as the causative agent of RAS but its role in its etiology has not been definitively proven. This study was primarily aimed to determine the role of HSV and Chlamydia trachomatis in the etiology of RAS.

Methods: 25 patients with RAS were included in the study. In biopsy samples taken from the patients, HSV was investigated by cell culture and DFA method, and C. trachomatis was investigated by Cell Culture,DFA methods in biopsy samples and ELISA methods in blood samples.

Results: HSV-1 and HSV-2 positivity were not found in cell culture and DFA test results. At the end of the first passage of cell culture for C.trachomatis with samples from 25 patients, suspectious/possible positivity was found in three patients(12%),and positivity was found in 16 patients (64%) as a result of DFA tests. When the serological test results of C.trachomatis were examined, only IgM(24%) antibodies were found in six patients, only IgG(24%) in six patients, and IgG and IgM antibodies together in two patients (8%).

Conclusion: In addition to the fact that HSV was not isolated in the patients in our study, it was not detected by DFA test, which may suggest that this factor does not play a role in the etiology of RAS. The positivity obtained from the C. trachomatis test results may be remarkable in associating RAS with C. trachomatis. Therefore, the role of C. trachomatis in RAS should be investigated by supporting it with other future studies.


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