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2022, Cilt 52, Sayı 3, Sayfa(lar) 232-239
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Retrospective Evaluation of Hepatitis Delta Virus Seroprevalence in HBsAg- Positive Patients
Canan Eryıldız1, Eray Özgün2, Zerrin Yuluğkural3, Ahmet Tezel4, Nermin Şakru1
1Trakya Üniversitesi, Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Edirne, Türkiye
2Trakya Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Edirne, Türkiye
3Trakya Üniversitesi, Tıp Fakültesi, Enfeksiyon Hastalıkları Anabilim Dalı, Edirne, Türkiye
4Trakya Üniversitesi, Tıp Fakültesi, Gastroenteroloji Bilim Dalı, Edirne, Türkiye
Keywords: Hepatitis delta virus, delta antibody, seroprevalence

Objective: The purpose of this study was to determine hepatitis delta virus (HDV) seroprevalence in patients with HBsAg and to examine hepatitis B serological markers and various biochemical parameters in patients with anti-HDV.

Methods: A total of 1831 patients with HBsAg admitted to our hospital between January 2015 and December 2021 and whose samples were sent to our laboratory for anti-HDV testing were included in the study. The test results of other hepatitis B serological markers, HBV DNA, anti-HCV, and anti-HDV of the patients were examined. In addition, levels of liver transaminase, serum bilirubin and albumin, platelet count, and INR values were analyzed retrospectively from hospital records.

Results: Anti-HDV testing was positive in 3.6% of HBsAg-positive patients. The anti-HDV-positivity rate was lower in males than in females (p=0.009). There was no statistically significant difference in anti-HDV-positivity rates according to years (p>0.05). The HBV-DNA-positivity rate in anti-HDV-negative patients was higher than in anti-HDV-positive patients (p=0.001). The rate of anti-HBe-positivity in anti-HDV-negative patients was higher than in anti-HDV-positive patients (p=0.001). Platelet count and albumin values were lower in patients with delta antibodies compared to patients without delta antibodies, while INR values were higher in these patients (p<0.01).

Conclusion: Anti-HDV-positivity, which occurred at a rate of 3.6% among HBsAg-positive patients, seems to be compatible with studies conducted in our country, especially in western regions. Considering the clinical course of hepatitis D infection, it is important to screen and follow-up of patients with hepatitis B infection to manage this disease.


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